Sorting Out Frontotemporal Dementia?
نویسندگان
چکیده
منابع مشابه
Sorting Out Frontotemporal Dementia?
Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) cause the neurodegenerative disease frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U). The receptor for PGRN in the CNS has not been previously identified. In this issue of Neuron, Hu and colleagues identify Sortilin (SORT1) as a key neuronal receptor for PGRN that facilitates its endocytosis and regulat...
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Objective Frontotemporal dementia (FTD) is an uncommon type of dementia. The hallmark feature of FTD is the presentation with aphasia, or behavioral changes which are varies in different subtypes of the disease. We propose a quantitative aphasia test as an additive diagnostic tool for differentiation of FTD subtypes. Method: The study was performed on 20 patients, who were referred to dementia...
متن کاملFrontotemporal dementia
OBJECTIVE Describe the relationships between the clinical, neuropsychological, and imaging findings from a group of patients diagnosed with frontotemporal dementia (FTD). METHODS The clinical histories, cognitive tests, and structural and perfusion brain images of 21 patients of the Psychiatric Hospital Universitario del Valle, Cali, Colombia, were reviewed. RESULTS The average age was 59.8...
متن کاملFrontotemporal dementia
Keywords Disease name / synonyms Included diseases Definition, clinical description and diagnostic criteria Differential diagnosis Diagnostic methods Epidemiology Etiology Genetic counseling Management including treatment Unresolved questions References Abstract Frontotemporal dementia (FTD) is the prototypical behavioural disorder arising from frontotemporal cerebral atrophy. Depending on the ...
متن کاملFrontotemporal dementia.
Frontotemporal dementia is a new name for clinical Pick's disease; the eponymic term PiD has been increasingly restricted to the pathologic variant with Pick bodies. This article describes the clinical picture, pathology, and genetic mechanisms of frontal lobe dementia. Frontotemporal dementia is still under-diagnosed and underestimated, partly because the individual components of the complex a...
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ژورنال
عنوان ژورنال: Neuron
سال: 2010
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2010.11.014